Systems Biology of the Cell Cycle
Bio Systems Analysis Group
Institute of Computer Science
Friedrich-Schiller-University Jena
07743 Jena, Germany
Team Collaborators
Peter Dittrich Stephan Diekmann
Bashar Ibrahim Eberhard Schmitt
Gerd Grüner  
Maiko Lohel Past Member
Katrin Bohl Margriet Palm
Sarah Werner


The growth of all organisms requires that the genome is accurately replicated and equally partitioned between two cellular progenies. In eukaryotes, the duplication of chromosomes, the separation of sister chromatids, and their segregation to opposite poles of the cell prior to cytokinesis are features of the cell cycle and grant maintenance of genomic integrity. Eukaryotic cells have evolved a surveillance mechanism for DNA segregation, the Mitotic Spindle Assembly Checkpoint (MSAC). This checkpoint blocks anaphase onset and prevents exit from mitosis until all chromosomes are properly attached and have aligned on the mitotic spindle. Its malfunction leads to cell death, generates aneuploidy, might facilitate tumorgenesis and aging , and might contribute to cancer.

The research focuses on modeling and simulation of the human's mitosis transition controls, the MSAC and the mitotic exit. Our modeling approaches base on biochemical reaction networks. We use In particular: Differential equations, stochastic simulation, evolutionary optimization, and three dimensional effects.



The MSAC, is the major cell cycle control mechanism in mitosis. It delays the transition from metaphase to anaphase until all chromosomes are correctly aligned at the metaphase spindle equator. In early metaphase, the chromosomes are not attached to the spindle of microtubules, while in late metaphase most chromosomes are attached. Once all kinetochores are attached, anaphase initiation is rapid. The subscript n denotes the number of chromosomes (e.g. n = 46 for human)






Peer-reviewed articles in international journals

Peer-reviewed articles in proceedings

For pdf or update see publications of the Group page